2 edition of Immunological studies in multiple low dose streptozotocin induced diabetes in mice. found in the catalog.
Immunological studies in multiple low dose streptozotocin induced diabetes in mice.
Ansar Iqbal Malik
by Aston University. Department of Pharmaceutical Sciences in Birmingham
Written in English
Thesis (PhD) - Aston University, 1988.
To investigate whether PDX-1 + stem cells are present in adult pancreas, we examined two animal models of diabetes. One model was produced by injecting adult mice with streptozotocin (SZ), a toxin that produces hyperglycemia due to rapid and massive β cell by: The hypoglycemic effect of the methanolic and aqueous extracts of whole parts of Cassia fistula in both normoglycemic and streptozotocin-nictotinamide induced Type 2 diabetic rats were investigated. Acute toxicity, oral glucose tolerance test and glucose uptake in isolated rat hemidiaphragm were performed in normal rats. Diabetes was induced in Sprague Dawley rats Cited by: 5.
Baik et al., "BCG Vaccine Prevents Insulitis in Low Dose Streptozotocin-Induced Diabetic Mice," Diabetes Research and Clinical Practice , cited by other. Ban et al., "Selective Death of Autoreactive T Cells in Human Diabetes by TNF or TNF Receptor 2 Agonism," 'l. Acad. Sci. USA , cited by : Leonardeuler. Abstract - The present study was designed to evaluate the oxidative stress as well as the therapeutic effect of Agaricus blazei Muril (A. Blazei) in rats with streptozotocin-induced diabetes. We used 25 Wistar rats, and DM was induced by injecting streptozotocin (70 mg/Kg i.p.).
The etiological heterogeneity of idiopathic diabetes has been recognized for 25 years, and subdivision into type 1 and type 2 diabetes is fundamental to the way we think about the disease. Review of the literature suggests that the concept of type 1 diabetes as an immunemediated disease emerged rapidly over the period from to and showed Cited by: Read "Normo-glycemic and hypolipidemic effect of costunolide isolated from Costus speciosus (Koen ex. Retz.)Sm. in streptozotocin-induced diabetic rats, Chemico-Biological Interactions" on DeepDyve, the largest online rental service for scholarly research with thousands of academic publications available at your fingertips.
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Mouse models of i nsulin dependen t diabetes: Low-dose streptocin-induced diabetes and nonobese diabetic (NOD) mice Diabetes M etab.
Rev., 3:  Lebwohl, B., R. Deckelbaum and P. Green. Antidiabetic effects of dietary administration of Aloe arborescens Miller components on multiple low-dose streptozotocin-induced diabetes in mice:. Kolb H () Mouse models of insulin dependent diabetes: low-dose streptozotocin-induced diabetes and nonobese diabetic (NOD) mice.
Diabetes Metab Rev 3: – PubMed CrossRef Google Scholar Kolb H, Oschilewski M, Schwab E, Oschilewski U, Kiesel U () Effect of cycloporin A on low-dose streptozotocin diabetes in by: Mencacci A, Romani L, Mosci P, Cenci E, Tonnetti L, Vecchiarelli A, Bistoni F.
Low-dose streptozotocin-induced diabetes in mice. Susceptibility to Candida albicans infection correlates with the induction of a biased Th2-like antifungal response. Cell Immunol. ; – doi: /cimmCited by: 7. To examine whether SFN prevents testicular apoptosis, type 1 diabetic mouse model was induced with multiple low-dose streptozotocin.
Diabetic and age-matched control mice were treated with and without SFN at mg/kg daily in five days of each. Streptozotocin diabetes mellitus can be induced via a single large dose or multiple low doses administration. It is possible that the first option to induce diabetes because of direct toxic effect of streptozotocin, while, low doses repeatedly administrated may exert blockage of insulin secretion [ Cited by: 1.
McEvoy RC, Andersson J, Sandler S, Hellerstrom C. Multiple, low dose streptozotocin induced diabetes in the mouse: Evidence for stimulation of a cytotoxic cellular immune response against an insulin producing beta cell line.
J Clin Invest; – PubMed Google ScholarCited by: 1. Nora Sarvetnick, Ph.D. – Principal Investigator DRC II UNMC, Omaha, NE Phone: EMAIL. Many questions regarding the pathogenesis of human autoimmune diabetes have not been answered, including the nature of the environmental stimulus and the identity of the cell subset responsible for precipitating disease.
In experimental studies conducted in diabetic type I mice or multiple low dose streptozotocin-induced diabetes mice (MLDS), infections by Taenia crassiceps was able to reduce hyperglycemia and insulitis preventing pancreatic damage probably by suppressing or modulating autoreactive T cells (Espinoza-Jimenez et al., ).
Interestingly Cited by: 6. In the low doses of streptozotocin (60 mg/kg body weight) model, treatment with 1,25(OH) 2 D 3 ( ng three times a week) reduced diabetes incidence from 85% to 45% in rats . In a study of Inaba et al. both the high- and the low-dose model of streptozotocin were used to test the effect of 1α(OH)D 3 on diabetes prevention .
The neutralization of IFNγ with mAbs or soluble receptors prevents NOD-mouse diabetes, 2, 8, 9, as well as diabetes induced by administration of multiple low-dose STZ (MDSD) in other strains. CYP greatly accelerates disease in NOD mice, and the CYP- and STZ-induced diseases are both associated with a burst of systemic and intra-islet Cited by: 1.
The treatment prevented diabetes from 75% in control down to 25% in week-old non-obese diabetic mice (4-week old mice received mg every 2 weeks until the 3rd injection and every 3 weeks thereafter), and restored normoglycemia in diabetic mice (blood glucose higher than 11 mM mice received mg twice a week for 5 week).Cited by: 1.
Animals were divided into four groups of five rats. In two groups, the animals were fasted for 12 hours and chemical diabetes was induced through an intraperitoneal injection of streptozotocin (50 mg/kg) (STZ, Sigma).
The STZ solution was prepared immediately prior injection by dissolving the drug in a fresh, cold citrate buffer, pH Cited by: 5. The RAW macrophage cells were used to evaluate the anti-oxidative and anti-inflammatory activity.
Thirty male Sprague-Dawley rats were induced by streptozotocin-nicotinamide for a diabetes model and fed either with three different doses of fucoxanthin (13, 26, and 65 mg/kg) or rosiglitazone ( mg/kg) for four by: 1.
SUMMARY Laboratory mice, rats, and rabbits may harbor a variety of viral, bacterial, parasitic, and fungal agents. Frequently, these organisms cause no overt signs of disease.
However, many of the natural pathogens of these laboratory animals may alter host physiology, rendering the host unsuitable for many experimental uses.
While the number and Cited by: Diabetes, scleroderma, oils and hormones The basic argument: Stress and aging make cells less responsive in many ways by damaging their ability to produce energy and to adapt. The polyunsaturated fats are universally toxic to the energy producing system, and act as a "misleading signal" channeling cellular adaptation down certain self-defeating.
For example, high doses of streptozotocin can rapidly induce diabetes in several strains of mice (16), and low doses can create a more chronic form of diabetes (17). Administration of polyinosinic polycytidylic acid (poly-IC), which has been used as a viral RNA mimic to stimulate the innate immune system, can induce insulitis and diabetes in /5.
Aldosterone and type 2 diabetes mellitus; 1,Dihydroxyvitamin D and type 2 diabetes: Ca-dependent molecular mechanisms and the role of vitamin D status; Suppressor of cytokine signaling 2 (SOCS2) deletion protects against multiple low dose streptozotocin-induced type 1 diabetes in adult male miceCited by: Professor Helen Thomas is head of the Immunology and Diabetes Unit at St Vincent’s Institute in Melbourne.
Her research is focused on prevention of type 1 diabetes. She aims to protect the insulin-producing cells in the pancreas from being destroyed by both the immune system and the stress that diabetes places on these cells.
She uses flow cytometry, imaging and molecular Founded: Table Prevention Type 1A Diabetes Onset. Nicotinamide The mechanism of nicotinamide protection is currently unknown ().Nicotinamide was shown initially to delay diabetes in NOD mice ().Nicotinamide inhibits poly(ADP-ribose) synthetase and, at high concentrations, can act as a free radical scavenger ().Pre-treatment with nicotinamide prevents the decrease in proinsulin.
Benefits of Ginsenosides to Diabetes. Studies have shown that ginsenoside Rg1 can improve glucose and lipid metabolisms and reduce blood glucose levels and insulin resistance indices in T2DM rats .Ginsenoside Ge can improve hyperglycemia by improving cholinergic and antioxidant systems in the brain of C57BL/6 mice and improve high-fat diet-induced insulin Cited by: 9.These mice more rapidly develop diabetes compared to standard NOD mice, with % of female mice developing disease between 7 and 15 weeks, rather than 80% between 16 and 40 weeks (12;13).
At this time, it is hypothesized that therapies that either eliminate insulitis completely or are effective in more robust animal models will better predict.In particular, some authors have challenged the efficacy of low-power LEDs used in LLLT In laboratory studies, LLLT radiant energy is almost entirely absorbed in the first 1 mm of skin, In two unrelated studies, LLLT diode devices proved to be ineffective in the treatment of diabetic neuropathy, in contrast with prior.